Citation:
Richard G. Gardner and Ravid, T. 2018. “From Precise Slicing To General Shredding: The Ubiquitin Ligase Ubr1 Roqs As A Multipurpose Protein Terminator”. Molecular Cell, 70, 6, Pp. 989-990. https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30448-9.
Abstract:
<p>In the current issue of Molecular Cell, Szoradi et al. (2018) present compelling data demonstrating how the newly identified SHRED pathway in yeast selectively shifts the E3 ligase Ubr1 specificity from N-end rule substrates to misfolded proteins in cells under proteostatic stress.</p>